Unusual, asymmetrical skin clouds with irregular edges or whose color and size change (potential signs of melanoma).
Persistent wounds that do not heal (which may indicate skin cancer).
Yellowing of the skin and eyes (jaundice) (associated with liver or pancreatic cancer).
Dark spots or intense itching (which may be associated with internal cancer).
Any unusual skin changes should be examined by a dermatologist or doctor, especially if it persists.